Asymmetric synthesis of the two enantiomers of β-phosphorus-containing α-amino acids <i>via</i> hydrophosphinylation and hydrophosphonylation of chiral Ni(<scp>ii</scp>)-complexes

Abstract

A new approach for the synthesis of the two enantiomers of β-phosphorus-containing α-amino acids was developed <italic>via</italic> Michael addition of secondary phosphine oxides and dialkyl phosphites to chiral Ni(<sc>ii</sc>)-complexes of a dehydroalanine-Schiff base.