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Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats

ImmunologyOxidative StressInflammationThrombosisPlasminogen ActivatorHematologyNeurologyMolecular SignalingYc-1 AttenuatesFibrinolysisHemorrhagic TransformationVascular BiologyImmune FunctionCerebral Blood FlowReperfusion InjuryPharmacologyIschemic StrokeEndothelial DysfunctionHemostasisMedicine