Host Genome-Wide Association Study of Infant Susceptibility to<i>Shigella</i>-Associated Diarrhea

Abstract

Shigella is a leading cause of moderate-to-severe diarrhea globally and the causative agent of shigellosis and bacillary dysentery. Associated with 80 to 165 million cases of diarrhea and &gt;13% of diarrheal deaths, in many regions, Shigella exposure is ubiquitous while infection is heterogenous.