<i>In Vitro</i> Susceptibility of <i>Plasmodium falciparum</i> Isolates from the China-Myanmar Border Area to Piperaquine and Association with Candidate Markers

Abstract

Plasmodium falciparum from the Greater Mekong subregion has evolved resistance to the artemisinin-based combination therapy dihydroartemisinin and the partner drug piperaquine. To monitor the potential westward spread or independent evolution of piperaquine resistance, we evaluated the in vitro susceptibility of 120 P. falciparum isolates collected at the China-Myanmar border during 2007 to 2016.