Doxycycline and its derivative, COL‐3, decrease dyskinesia induced by <scp>l</scp>‐DOPA in hemiparkinsonian rats

Abstract

The present study demonstrates the anti-dyskinetic potential of doxycycline and its analogue compound COL-3 in hemiparkinsonian rats. Given the long-established and safe clinical use of doxycycline, this study suggests that these drugs might be tested to reduce or prevent l-DOPA-induced dyskinesia in Parkinson's patients.