Concepedia

Synthesis and application of a <sup>19</sup>F-labeled fluorescent nucleoside as a dual-mode probe for i-motif DNAs

Wen Ann Wee, Ji Hye Yum, Shingo Hirashima, Hiroshi Sugiyama, Soyoung Park

RSC Chemical Biology · 2021 · 15 citations · 48 references

DOIFull text

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Concepts

Abstract

We report on the first bifunctional cytidine-based probe (FPdC) that displays high quantum yield and sensitive <sup>19</sup>F NMR signal. FPdC was used to investigate a noncanonical DNA structure, and displayed significant response to i-motif formation.

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