Formulation and Characterization of Atenolol-loaded Gellan Gum Nanoparticles

Abstract

Biopolymeric nanoparticles were synthesized using Gellan Gum and loaded with Atenolol, an antihypertensive drug by ionotropic gelation (an easy and ecofriendly system) induced by BaCl2 as an ionic crosslinking agent to improve absorption and bioavailability of drug. These nanoparticles were characterized by scanning electron microscope, fourier-transform infrared spectroscopy, X-ray diffraction analysis and dynamic light scattering techniques. Mean particle size obtained was 85.61 nm by X-ray diffraction, Zeta potential -19.4 mV with fibrous morphology. In order to optimize conditions for in vitro drug release various physicochemical parameters were studied. Different kinetics model were used to analyze in vitro drug release and results indicated that the drug release follows Korsemeyer-Peppa’s model.