Science Translational Medicine · 2021 · 359 citations · 55 references
Life SciencesImmunologyPharmacotherapyAutoimmunityImmunoregulationImmunotherapyCell-mediated ImmunityEffector T Cell FunctionT Cell BiologyT Cell DifferentiationT Cell ExhaustionT Cell PharmacologyBeta FunctionPancreatic Beta-cell FunctionT Cell Exhaustion ReversalT Cell Exhaustion SignalingT Cell-based ImmunotherapyT Cell-mediated Immune ResponseT-cell Mediated Immune ResponseT-cell Mediated Responses
T cell subsets indicated that partially exhausted effector cells were associated with clinical response. Thus, this trial showed improvement in metabolic responses and delay of diabetes with immune therapy.
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Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children
Anette G. Ziegler, Marian Rewers, Olli Simell et al. · JAMA · 2013 · 1.3K citations · Full text
Medicine, Endocrinology, Pediatrics +13
Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus
Kevan C. Herold, William Hagopian, Julie Auger et al. · New England Journal of Medicine · 2002 · 1.2K citations · Full text
An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes
Kevan C. Herold, Brian N. Bundy, S. Alice Long et al. · New England Journal of Medicine · 2019 · 1.1K citations · Full text
Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes
Bart Keymeulen, Evy Vandemeulebroucke, Anette G. Ziegler et al. · New England Journal of Medicine · 2005 · 1.1K citations · Full text
Medicine, Endocrinology, Immunology +17