ACS Applied Bio Materials · 2021 · 44 citations · 61 references
Natural SciencesMaterials EngineeringMaterials ScienceNanomaterialsNanotechnologyTheranosticsCancer NanomedicineGraphene NanomaterialsMagnetic Resonance ImagingNanomedicineQuantum DotsTheranostic NanoparticlesBioimagingContrast Agent RelaxivityGrapheneGraphene Quantum DotsIn Vivo StudiesMultifunctional NanomaterialsNanoparticle Imaging AgentsNanoparticle-based Contrast Agents
A single-atom metal doped on carbonaceous nanomaterials has attracted increasing attention due to its potential applications as high-performance catalysts. However, few studies focus on the applications of such nanomaterials as nanotheranostics for simultaneous bioimaging and cancer therapy. Herein, it is pioneeringly demonstrated that the single-atom Gd anchored onto graphene quantum dots (SAGd-GQDs), with dendrite-like morphology, was successfully prepared. More importantly, the as-fabricated SAGd-GQDs exhibits a robustly enhanced longitudinal relaxivity (r1 = 86.08 mM–1 s–1) at a low Gd3+ concentration of 2 μmol kg–1, which is 25 times higher than the commercial Gd-DTPA (r1 = 3.44 mM–1 s–1). In vitro and in vivo studies suggest that the obtained SAGd-GQDs is a highly potent and contrast agent to obtain high-definition MRI, thereby opening up more opportunities for future precise clinical theranostics.
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Hydrothermal Route for Cutting Graphene Sheets into Blue‐Luminescent Graphene Quantum Dots
Dengyu Pan, Jingchun Zhang, Zhen Li et al. · Advanced Materials · 2009 · 2.8K citations