Concepedia

Publication | Open Access

Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier

DOIFull Paper Access

33

Citations

65

References

2021

Year

Annika Möller‐Kerutt, Juan Eduardo Rodriguez-Gatica, Karin Wacker, Rohan Bhatia, Jan Peter Siebrasse, Nanda Boon, Veerle Van Marck, Peter Boor, Ulrich Kubitscheck, Jan Wijnholds,
Journal of the American Society of Nephrology

Abstract

Crb2 is an essential component of the podocyte's slit diaphragm, interacting with Nephrin. Loss of slit diaphragm targeting and increasing ER stress are pivotal factors for onset and progression of CRB2-related SRNS.

References

YearCitations

Page 1