Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against <i>Mycobacterium tuberculosis</i>

Lei Li, Logan W. MacIntyre, Thahmina Ali, Riccardo Russo, Bimal Koirala, Yözen Hernández, Sean F. Brady

Journal of Natural Products · 2021 · 29 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

growth in murine macrophages and increases the activities of ClpC1 ATPase and the associated ClpC1/P1/P2 protease complex, thus causing cell death by uncontrolled protein degradation.

References

30