Inactivation of SERCA2 Cys⁶⁷⁴ accelerates aortic aneurysms by suppressing PPARγ

Abstract

The inactivation of SERCA2 C674 promotes the development of aortic aneurysms by disrupting the balance between PPARγ and NFAT/NF-κB. Our study highlights the importance of C674 redox status in regulating PPARγ to maintain aortic homeostasis.