Histological and immunohistochemical changes in facial skin treated with combined ablative and non‐ablative laser therapy

Abstract

BACKGROUND: Facial skin rejuvenation is a highly sought after procedure. Different materials, energy-based devices and techniques have been shown to offer good results in facial rejuvenation. AIMS: The aim of this study was to evaluate the macroscopic and histological and immunohistochemical changes in facial skin treated with a combined laser therapy. PATIENTS/METHODS: Fourteen patients aged from 38 to 59 years were included in the study. Two different wavelengths (2940 and 1064 nm) were used in this four-step procedure. RESULTS: Significant improvement according to classification for age-related changes in all areas of the face was achieved. There were also significant structural changes in the epidermis and dermis, confirmed with histology and immunohistochemistry. CONCLUSION: The dual-wavelength protocol has been found to provide excellent results for facial rejuvenation.