Tracking the Emergence of Azithromycin Resistance in Multiple Genotypes of Typhoidal <i>Salmonella</i>

Abstract

In the early 1900s, with mortality of ∼30%, typhoid and paratyphoid (caused by Salmonella Typhi and Paratyphi A) ravaged parts of the world; with improved water, sanitation, and hygiene in resource-rich countries and the advent of antimicrobials, mortality dwindled to &lt;1%. Today, the burden rests disproportionately on South Asia, where the primary means for combatting the disease is antimicrobials.