Concepedia

Efficacy of LGE‐MRI‐guided fibrosis ablation versus conventional catheter ablation of atrial fibrillation: The DECAAF II trial: Study design

Nassir F. Marrouche, Tom Greene, J. Michael Dean, Eugene Kholmovski, Leonie Morrison‐de Boer, Moussa Mansour, Hugh Calkins, Francis E. Marchlinski, David J. Wilber, Gerhard Hindricks,

Journal of Cardiovascular Electrophysiology · 2021 · 84 citations · 30 references

DOI

Abstract

The DECAAF II trial is the first prospective, randomized, multicenter trial of patients with persistent AF using imaging defined atrial fibrosis as a treatment target. The trial will help define an optimal approach to catheter ablation of persistent AF, further our understanding of influencers of ablation lesion formation, and refine selection criteria for ablation based on atrial myopathy burden.

References

30

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Gerhard Hindricks, Tatjana Potpara, Nikolaos Dagres et al. · European Heart Journal · 2020 · 9.6K citations · Full text

2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design: A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology (ESC) and the European Cardiac Arrhythmia Society (ECAS); and in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), the Asia Pacific Heart Rhythm Society (APHRS), and the Society of Thoracic Surgeons (STS). Endorsed by the governing bodies of the American College of Cardiology Foundation, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, the Asia Pacific Heart Rhythm Society, and the Heart Rhythm Society

Hugh Calkins, Karl Heinz Kuck, Riccardo Cappato et al. · EP Europace · 2012 · 2.7K citations · Full text

Approaches to Catheter Ablation for Persistent Atrial Fibrillation

Atul Verma, Chenyang Jiang, Timothy R. Betts et al. · New England Journal of Medicine · 2015 · 2.2K citations · Full text

Association of Atrial Tissue Fibrosis Identified by Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation

Nassir Marrouche, David J. Wilber, Gerhard Hindricks et al. · JAMA · 2014 · 1.4K citations · Full text

Detection and Quantification of Left Atrial Structural Remodeling With Delayed-Enhancement Magnetic Resonance Imaging in Patients With Atrial Fibrillation

Robert S. Oakes, Troy J. Badger, Eugene Kholmovski et al. · Circulation · 2009 · 1.1K citations · Full text