Concepedia

Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing

Emma Arnesdotter, Eva Gijbels, Bruna dos Santos Rodrigues, Vânia Vilas‐Boas, Mathieu Vinken

Methods in molecular biology · 2022 · 17 citations · 23 references

Concepts

PharmacyClinical ToxicologyToxicologyMechanisms Of ToxicityToxicodynamicsAdverse Outcome PathwaysHepatic Function TestingHepatic PathophysiologyHepatic ToxicityHepatotoxicity MechanismsLiver DiseaseAdverse Outcome Pathway DevelopmentAdverse Outcome Pathway ValidationHepatic Adverse EffectsHepatic Adverse Event GradingLiver Toxicity AssessmentNetwork-based Adverse Outcome PathwaysQuantitative Adverse Outcome Pathways

References

23

The environment and disease: association or causation?

Austin Bradford Hill · Journal of the Royal Society of Medicine · 2015 · 7.3K citations · Full text

Public Health, Environmental Sciences, Environmental Health +9

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

Daniel L. Villeneuve, Doug Crump, Natàlia García‐Reyero et al. · Toxicological Sciences · 2014 · 711 citations · Full text

Pharmacy, Toxicology, Mechanisms Of Toxicity +15

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

Richard A. Becker, Gerald T. Ankley, Stephen W. Edwards et al. · Regulatory Toxicology and Pharmacology · 2015 · 259 citations · Full text

Pharmacy, Risk Management, Evidence-based Practice +15

Adverse Outcome Pathway Development II: Best Practices

Daniel L. Villeneuve, Doug Crump, Natàlia García‐Reyero et al. · Toxicological Sciences · 2014 · 257 citations · Full text

Pharmacy, Systems Biology, Toxicology +17

Adverse outcome pathway networks I: Development and applications

Dries Knapen, Michelle Angrish, Marie Fortin et al. · Environmental Toxicology and Chemistry · 2018 · 235 citations · Full text

Pharmacy, Toxicology, Environmental Toxicology +12