Intratumoral CXCL13⁺CD8⁺T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

Abstract

Intratumoral CXCL13⁺CD8⁺T cells infiltration indicated inferior clinical outcome in patients with ccRCC. CXCL13⁺CD8⁺T cells possessed increased exhausted markers, decreased effector molecules and better proliferation ability. CXCL13⁺CD8⁺T cells abundance impaired total CD8⁺T cells' immune function. Intratumoral CXCL13⁺CD8⁺T cells abundance was associated with immunoevasive contexture. The abundance of CXCL13⁺CD8⁺T cells was an independent prognosticator and a potential immunotherapeutic target marker for ccRCC treatment.