Concepedia

KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma

Yuhang Jiang, Fengfeng Li, Bowen Gao, Mengjun Ma, Chen Meng, Yanfeng Wu, Weidong Zhang, Yangbai Sun, Sanhong Liu, Huiyong Shen

Theranostics · 2021 · 83 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

Collectively, we elucidated that upregulated KDM6B facilitates tumor metastasis in OS via modulating LDHA expression. Our findings deepen the recognition of OS metastasis mechanism and suggest that KDM6B might be a new potential therapeutic target for the treatment of OS (especially highly metastatic OS).

References

30

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan, Matthew J. Ryan, Harshil Dhruv et al. · Nature · 2017 · 2K citations · Full text

, , +16

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Valeria R. Fantin, Julie St‐Pierre, Philip Leder · Cancer Cell · 2006 · 1.6K citations · Full text

, , +16

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Anne Le, Charles R. Cooper, Arvin M. Gouw et al. · Proceedings of the National Academy of Sciences · 2010 · 1.5K citations · Full text

, , +17

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer et al. · Science · 2020 · 1.3K citations · Full text

, , +15

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Laurens Kruidenier, Chun‐wa Chung, Zhongjun Cheng et al. · Nature · 2012 · 958 citations · Full text

, , +14