System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan

Abstract

We identified 37 blood eGenes predicted causally associated with CAD. The predicted expression for 6 eGenes impacted the lifespan potential through the risk of CAD. Prioritization based on network, annotations, and single-cell expression identified targets deemed tractable for the development of drugs and for drug repurposing.