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Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance

InflammationPain ResearchMorphine-induced Antinociceptive ToleranceMedicineImmunologyNeuropathic PainNlrp3 ActivationNeuropharmacologyBrain-immune InteractionNeurosciencePain MechanismPharmacologyNeuroimmunologyNeuroinflammation