Antiviral Bafilomycins from a Feces-Inhabiting <i>Streptomyces</i> sp.

Abstract

A new bafilomycin derivative (<b>1</b>) and another seven known bafilomycins (<b>2</b>-<b>8</b>) were isolated from feces-derived <i>Streptomyces</i> sp. HTL16. The structure of <b>1</b> was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC₅₀ values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.