Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines

Abstract

The first Ni(OTf)₂-catalyzed hydroamination of ynamides <b>2</b> was developed by reacting with secondary amines (<b>1</b> and <b>4</b>). This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds were prepared in moderate to excellent yields with high regioselectivities.