Mineralocorticoid Receptor in Smooth Muscle Contributes to Pressure Overload–Induced Heart Failure

Abstract

These results provide a novel paradigm by which MR inhibition may be beneficial in HF by blocking MR in SMC, thereby improving cardiac blood supply in the setting of pressure overload-induced hypertrophy, which in turn mitigates the adverse cardiac remodeling that contributes to HF progression and symptoms.