In Silico Studies of Lamiaceae Diterpenes with Bioinsecticide Potential against Aphis gossypii and Drosophila melanogaster

Abstract

Structure analysis revealed <i>ent</i>-kaurane, kaurene, and clerodane diterpenes as the most active, showing excellent results. We also found that the interactions formed by these compounds were more stable, or presented similar stability to the commercialized insecticides tested. Overall, we concluded that the compounds bistenuifolin L (<b>1836</b>) and bistenuifolin K (<b>1931</b>), were potentially active against <i>A. gossypii</i> enzymes<i>;</i> and salvisplendin C (<b>1086</b>) and salvixalapadiene (<b>1195</b>), are potentially active against <i>D. melanogaster</i>. We observed and highlight that the diterpenes bistenuifolin L (<b>1836</b>), bistenuifolin K (<b>1931</b>), salvisplendin C (<b>1086</b>), and salvixalapadiene (<b>1195</b>), present a high probability of activity and low toxicity against the species studied.