Cu-Catalyzed radical-triggered spirotricyclization of enediynes and enyne-nitriles for the synthesis of pentacyclic spiroindenes

Abstract

A new copper-catalyzed radical-triggered fluoromethylation-spirotricyclization of enediyne- and enyne-nitrile-containing<italic>para</italic>-quinone methides (<italic>p</italic>-QMs) was reported for the first time, and used to produce a series of hitherto unreported pentacyclic spiroindenes.