Nonpeptide small molecules with a ten-membered macrolactam or a morpholine motif from the insect American cockroach and their antiangiogenic activity

Abstract

(±)-Periplactam A (<bold>1</bold>), a rare ten-membered macrolactam composed of lignan and putrescine, (±)-periplanol E (<bold>2</bold>), a dimeric phenethyl alcohol derivative formed <italic>via</italic> morpholine, and periplactams B (<bold>3</bold>) and C (<bold>4</bold>) were isolated from American cockroach.