Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome

Abstract

Our data revealed disease-specific immune cell subsets and provided some potential new targets of pSS. Specific expansion of CD4⁺ CTLs may be involved in the pathogenesis of pSS, which might give valuable insights for therapeutic interventions of pSS.