R and D Management · 2021 · 178 citations · 35 references
ManagementInfectious DiseasesInnovation ManagementEmerging Infectious DiseasesInnovationInnovation StrategyDisruptive InnovationInnovation PolicyTechnological InnovationDisruptive Technology AnalysisHealth System InnovationInnovation Diffusion In HealthcareKey InnovationsMedical InnovationSystemic Crisis ManagementTechnology Diffusion Analysis
Technology evolution in the face of environmental threats is a central issue in technology analysis and innovation management. The study aims to analyze critical innovations that address COVID‑19 and to develop propositions for a general crisis‑innovation model. Using a narrative approach grounded in technological exaptation theory, the authors examined how drugs originally intended for other diseases, such as Remdesivir and Tocilizumab, were repurposed to treat COVID‑19. Technological exaptation, particularly with longer exaptive distances, can drive rapid innovation for COVID‑19 and similar crises, offering a new perspective on innovation evolution under environmental threats.
One of the key issues in the field of technology analysis and innovation management is how new technologies origin and evolve in the presence of environmental threats. We confront this problem focusing on emerging innovative solutions to cope with unexpected and harmful problems posed by crises and needing a rapid, effective response. We specifically analyze the patterns of critical innovations to cope with new coronavirus disease (COVID‐19) that is generating public health and economic issues worldwide. Accordingly, in the context of the theory of technological exaptation, we adopted a narrative approach examining vital innovations that ended up treating COVID‐19 even though they were originated to treat other diseases (more or less distant from the COVID‐19 domain), as the antiviral drug Remdesivir and the antirheumatoid arthritis drug Tocilizumab. Results reveal that technological exaptation, especially if characterized by a longer exaptive distance, is a potential driving force of innovation to cope with COVID‐19 in the short‐term and other similar issues. On this basis, we provide propositions for a more general crisis model of innovation. This study adds a new perspective that may be helpful to explain the evolution of innovation in the presence of crises, considering technological exaptation in a context of environmental threats.
35
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren, Robert Jordan, Michael K. Lo et al. · Nature · 2016 · 1.6K citations · Full text
Christine M. Pearson, Judith A. Clair · Academy of Management Review · 1998 · 1.4K citations
Management, Organization Studies, Organizational Behavior +13
Emmie de Wit, Friederike Feldmann, Jacqueline Cronin et al. · Proceedings of the National Academy of Sciences · 2020 · 946 citations · Full text
Judith A. Clair · Academy of Management Review · 1998 · 826 citations