Systemic Hypertension · 2021 · 12 citations · 8 references
MedicineCardiologyCardiovascular PharmacotherapyRenal PathophysiologyVascular SurgeryBlood Pressure ManagementBlood Pressure RegulationHypertension ManagementRenal Artery InterventionRenal PhysiologyAntihypertensive TreatmentBlood PressureRandomized Clinical TrialsSympathetic ActivationSympathetic Nervous System InvolvementSympathetic Nervous System ModulationSympathetic Nervous System Physiology
Hyperactivity of the sympathetic nervous system is one of the basic mechanisms in the development of arterial hypertension (AH). Transcatheter renal artery denervation is aimed to destroy the renal sympathetic afferent and efferent nerves to achieve a sustained reduction in blood pressure. Since 2017, all II generation studies have demonstrated that sympathetic denervation provides clinically significant BP reduction. Russian Medical Society for Arterial Hypertension (RMSAH) experts consider SD as a possible addition to the antihypertensive strategy in patients with uncontrolled AH and recommend denervation of the renal arteries in registers and clinical trials. On the basis of existing randomized clinical trials, as well as the experience of radiofrequency denervation in Russia, the experts of RMSAH present a consensus and view of the current situation in the field of renal denervation.
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A Controlled Trial of Renal Denervation for Resistant Hypertension
Deepak L. Bhatt, David E. Kandzari, William W. O’Neill et al. · New England Journal of Medicine · 2014 · 2.2K citations
Predictors of blood pressure response in the SYMPLICITY HTN-3 trial
David E. Kandzari, Deepak L. Bhatt, Sandeep Brar et al. · European Heart Journal · 2014 · 540 citations · Full text
Michael Böhm, Felix Mahfoud, Raymond R. Townsend et al. · European Heart Journal · 2018 · 85 citations
European Society of Hypertension position paper on renal denervation 2018
Roland E. Schmieder, Felix Mahfoud, Michel Azizi et al. · Journal of Hypertension · 2018 · 66 citations · Full text
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