Concepedia

Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway

Ming‐Hui Sun, Weijun Wang, Lingtian Min, Cheng Chen, Qing Li, Wenjie Weng

Journal of Orthopaedic Surgery and Research · 2021 · 18 citations · 20 references

DOIFull text

Open access

Abstract

SFRP5 could alleviate LPS-induced ATDC5 cell inflammation and apoptosis; these actions may rely on repressing Wnt5a/JNK activation.

References

20

Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis

Timothy F. Day, Xizhi Guo, Lisa Garrett‐Beal et al. · Developmental Cell · 2005 · 1.6K citations · Full text

, , +7

Wnt signal transduction pathways

Yuko Komiya, Raymond Habas · Organogenesis · 2008 · 1.5K citations · Full text

Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

Noriyuki Ouchi, Akiko Higuchi, Koji Ohashi et al. · Science · 2010 · 490 citations · Full text

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Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

Mei Zhu, Dezhi Tang, Qiuqian Wu et al. · Journal of Bone and Mineral Research · 2008 · 474 citations · Full text

, , +16

Expression and function of wingless and frizzled homologs in rheumatoid arthritis

Malini Sen, Kevin Lauterbach, Hani El‐Gabalawy et al. · Proceedings of the National Academy of Sciences · 2000 · 314 citations · Full text