Concepedia

MOTS-c reduces myostatin and muscle atrophy signaling

Hiroshi Kumagai, Ana R. Coelho, Junxiang Wan, Hemal H. Mehta, Kelvin Yen, Amy Huang, Hirofumi Zempo, Noriyuki Fuku, Seiji Maeda, Paulo J. Oliveira,

American Journal of Physiology-Endocrinology and Metabolism · 2021 · 61 citations · 41 references

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Concepts

Abstract

MOTS-c, a mitochondrial-derived peptide reduces high-fat-diet-induced muscle atrophy signaling by reducing myostatin expression. The CK2-PTEN-mTORC2-AKT-FOXO1 pathways play key roles in MOTS-c action on myostatin expression.

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