Concepedia

Trafficking of JC virus-like particles across the blood–brain barrier

Dong Ye, Tina Zimmermann, Victoria Demina, Sergey Sotnikov, Christian Ried, Harri Rahn, Marcus Stapf, Christopher Untucht, Michael Rohe, Georg C. Terstappen,

Nanoscale Advances · 2021 · 24 citations · 36 references

DOIFull text

Open access

Concepts

Abstract

. VLPs were found to interact with sialic acid glycans in mouse brain endothelia. The ability of JC VLPs to cross the BBB can be useful in developing a delivery system for transport of genes and small molecule cargoes to the brain.

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