Allergen‐specific immunotherapy induces the suppressive secretoglobin 1A1 in cells of the lower airways

Abstract

Allergen-specific immunotherapy induces a yet unknown local gene expression footprint in the lower airways that on one hand appears to be a result of multiple regulatory pathways and on the other hand reveals SCGB1A1 as novel anti-inflammatory mediator of long-term allergen-specific therapeutic intervention in the local environment.