Concepedia

CSF parvalbumin levels reflect interneuron loss linked with cortical pathology in multiple sclerosis

Roberta Magliozzi, Marco Pitteri, Stefano Ziccardi, Anna Isabella Pisani, Luigi Montibeller, Damiano Marastoni, Stefania Rossi, Valentina Mazziotti, Maddalena Guandalini, Caterina Dapor,

Annals of Clinical and Translational Neurology · 2021 · 36 citations · 35 references

DOIFull text

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Abstract

CSF-PVALB levels reflect loss of cortical interneurons in MS patients with more severe disease course and might represent an early, new MS-specific biomarker of cortical neurodegeneration, atrophy, and cognitive decline.

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