Myocardial Expression of Somatotropic Axis, Adrenergic Signalling, and Calcium Handling Genes in Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction

Abstract

Heart failure with reduced ejection fraction and HFpEF patients with stable clinical condition display a distinct molecular milieu of genes involved in somatotropic axis regulation, calcium handling, and adrenergic derangement at a myocardial level. The unique opportunity to compare these results with a control group, as reference population, may contribute to better understand HF pathophysiology and to identify novel potential therapeutic targets that could be modulated to improve ventricular function in patients with HF.