Synthesis of C3-sulfone substituted naphthols <i>via</i> rhodium(<scp>iii</scp>)-catalyzed annulation of sulfoxonium ylides with alkynylsulfones

Abstract

C-H activation of sulfoxonium ylides catalyzed by rhodium(iii) with subsequent annulation by alkynylsulfones was accomplished. This methodology offers a step-economical approach for assembling C3-sulfone-substituted naphthols with a high level of regioselectivity that is complementary to previous protocols. The approach has an extensive substrate spectrum and broad functional group tolerance.