Concepedia

Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents

Evgeniy A. Gusakov, Iuliia Topchu, Aleksandra Mazitova, Igor V. Dorogan, Emil Bulatov, Ilya G. Serebriiskii, Inna O. Tupaeva, Duong Ngoc Toan, Duong Nghia Bang, Yanis Boumber,

RSC Advances · 2021 · 17 citations · 30 references

DOI Full text

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Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryOrganic ChemistryHeterocyclic ChemistryMacrocycle SynthesisMacrocyclic Drug DesignNatural Product-based Drug DesignPharmacodynamics Of Anticancer AgentsTarget-oriented SynthesisBiologic EfficacyBiological Evaluation PlanningBiological Evaluation ReportMedicinal HeterocyclesQuinoline ChemistryQuinoline Synthesis

Abstract

also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents.