Apolipoprotein L1 risk genotypes in Ghanaian patients with systemic lupus erythematosus: a prospective cohort study

Abstract

<i>APOL1</i> RVs were heritable risk factors for morbidity and mortality in this Ghanaian SLE cohort. Despite no appreciable differences in SLE activity, <i>APOL1</i> high-risk patients exhibited progressive renal disease, organ damage accrual and a 13-fold higher case fatality.