Brain and Placental Pathology in Fetal COL4A1 Related Disease

Abstract

These cases confirm that small vessel disease is important in producing intracranial pathology in <i>COL4A1</i>mutation. We report an arteriopathy distinct from microvascular thrombosis and demonstrate that placental pathology is common in fetal COL4A1 related disease. This tentatively suggests that placental pathology may contribute to CNS abnormalities by affecting circulatory sufficiency.