Significance of Oncotype DX 21-Gene Test and Expression of Long Non-Coding RNA MALAT1 in Early and Estrogen Receptor-Positive Breast Cancer Patients

Abstract

<i>MALAT1</i> is a novel breast cancer biomarker independent of tumor stage, disease grade and lymph node status. <i>MALAT1</i> level is associated with the Oncotype <i>DX 21-gene</i> RS value. Therefore, combination of <i>MALAT1</i> and the Oncotype <i>DX 21-gene</i> test may be used to predict prognosis in ER⁺ and early stage breast cancer.