Chiral Lewis acid-bonded picolinaldehyde enables enantiodivergent carbonyl catalysis in the Mannich/condensation reaction of glycine ester

Abstract

The catalytic asymmetric Mannich/condensation of glycine ester with aldimines was achieved by merging chiral<italic>N</italic>,<italic>N</italic>′-dioxide/Yb^IIIcomplex Lewis acid catalysis/carbonyl catalysis under mild condition.