The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females

Abstract

<b>Context:</b> Research has shown the modulations of Follistatin (FST) and Myostatin (MST) following weight loss.<b>Objective:</b> We evaluated the effects of gradual weight loss (GWL) and rapid weight loss (RWL) on serum MST, FST, and body composition in overweight and obese females.<b>Materials and methods:</b> Thirty-six overweight and obese females successfully completed the study interventions: GWL (<i>n</i> = 18) or RWL (<i>n</i> = 18). Serum MST and FST concentrations, as well as anthropometric measurements, were collected at baseline and at the conclusion of each weight loss intervention.<b>Results:</b> MST concentration significantly (<i>p</i> < .05) decreased in the GWL; while FST concentration, body fat percentage and skeletal muscle mass significantly declined in both conditions. The loss in skeletal muscle mass was significantly greater in RWL relative to GWL.<b>Discussion and conclusion:</b> GWL was more effective than RWL in preserving skeletal muscle mass in overweight and obese females. Moreover, GWL leads to declines in MST concentrations.