Synlett · 2021 · 31 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCatalyst SynthesisCatalytic MaterialsCatalytic MechanismsCross-coupling ReactionsHeterocycle SynthesisHeterocyclic ChemistryHeterocycle FunctionalizationIsoxazole ChemistryIsoxazole SynthesisMetal CarbenesNitrene Transfer ReactionsNitrogen-bearing Molecules
Abstract During the past two decades, gold-catalyzed nitrene-transfer reactions via α-imino gold carbenes have received extensive attention, as this strategy provides rapid access to nitrogen-containing molecules with high efficiency. In this review, we focus on recent progress in gold-catalyzed formal annulations of ynamides with isoxazole derivatives as nitrene-transfer reagents via α-imino gold carbenes in atom-economic and rapid construction of N-heterocycles.