Two new sesquiterpenes from the rhizomes of <i>Atractylodes macrocephala</i> and their biological activities

Abstract

Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (<b>1</b>) and selina-4(14),11-dien-7-ol (<b>2</b>), along with two known compounds were isolated from rhizomes of <i>Atractylodes macrocephala</i> Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of <b>1</b> was established by TDDFT-ECD calculations. Compound <b>1</b> was found to moderately inhibit LSD1 activity with IC₅₀ value of 34.0 μM. Compounds <b>1</b> and <b>4</b> exhibited a regulate effect on Keap1-Nrf2-ARE pathway.[Formula: see text].