Concepedia

ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1

Zhenbo Han, Xiuxiu Wang, Zihang Xu, Yang Cao, Rui Gong, Yu Yang, Ying Yu, Xiaofei Guo, Shenzhen Liu, Meixi Yu,

Theranostics · 2021 · 164 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

A-YTHDF1-YAP axis in the regulation of CMs to re-enter the cell cycle. This finding suggests a novel potential therapeutic strategy for cardiac regeneration.

References

30

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

Zejuan Li, Hengyou Weng, Rui Su et al. · Cancer Cell · 2016 · 1.6K citations

, , +17

m <sup>6</sup> A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

Shay Geula, Sharon Moshitch-Moshkovitz, Dan Dominissini et al. · Science · 2015 · 1.6K citations · Full text

, , +17

m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program

Sicong Zhang, Boxuan Zhao, Aidong Zhou et al. · Cancer Cell · 2017 · 1.6K citations

, , +17

Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

Dali Han, Jun Liu, Chuanyuan Chen et al. · Nature · 2019 · 990 citations

, , +12

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

Yang Xiang, Benoît Laurent, Chih-Hung Hsu et al. · Nature · 2017 · 966 citations · Full text

, , +14