The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients

Abstract

HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+) and that HLA-B^*27:04 was the dominant HLA-B27 subtype (<i>N</i> = 224). In all participants, HLA^*27:04 homozygous were only detected in two patients. In the HLA-B27(+) group, HLA-B40 was observed in 51 cases and one control (<i>p</i> < 0.05, OR = 7.87, 95% CI 1.05-59.0); of these, the most genotype was HLA-B^*27:04/B^*40:01(<i>N</i> = 38). Two hundred thirty-nine patients' clinical information was recorded. Cases with HLA-B27/B46 had more peripheral joint involvement (OR = 3.95, 95% CI 1.77-8.79) in HLA-B27(+) AS. HLA-B^*15:02 may be a significant risk element to peripheral joint involvement (<i>p</i> < 0.05) in HLA-B27(-) patients. Therefore, we believe HLA-B^*40:01, HLA-B^*46:01, and HLA-B^*15:02 can be the test indicators for AS diagnostic value.