The Rise of Molecular Glues

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

Life Sciences, Biochemistry, Molecular Biology +8

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

Antonio Di Stasi, Siok‐Keen Tey, Gianpietro Dotti et al. · New England Journal of Medicine · 2011 · 1.5K citations · Full text

Life Sciences, Biotechnology, Immunology +13

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

David M. Sabatini · Proceedings of the National Academy of Sciences · 2017 · 499 citations · Full text

Life Sciences, Biochemistry, Physiology +16

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

Barbara E. Bierer, Patricia K. Somers, Thomas J. Wandless et al. · Science · 1990 · 356 citations

Medicine, Immunology, Pharmacology +15

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

Stephen J. Haggarty, Thomas U. Mayer, David T. Miyamoto et al. · Chemistry & Biology · 2000 · 250 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16