Evolution of Cefiderocol Non-Susceptibility in<i>Pseudomonas aeruginosa</i>in a Patient Without Previous Exposure to the Antibiotic

Abstract

We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.