Rational design of a lysosome-targeting and near-infrared absorbing Ru(<scp>ii</scp>)–BODIPY conjugate for photodynamic therapy

Abstract

A Ru(ii)-BODIPY conjugate has been rationally designed and exhibits an intense absorption in the NIR region to boost lysosome-targeted PDT in vitro and in vivo. The advantages of Ru(ii) and BODIPY were successfully instilled into the conjugate to yield highly effective PDT efficacy against malignant melanoma A375 cells (PI = 3448) and A375 mice xenografts.