Headache during SARS‐CoV‐2 infection as an early symptom associated with a more benign course of disease: a case–control study

Abstract

Our results show that headache is associated with a more benign SARS-CoV-2 infection. COVID-19-associated headache appears as an early symptom and as a novel headache with characteristics of headache attributed to systemic viral infection. Further research addressing the underlying mechanisms to confirm these findings is warranted.